Organic Synthesis is, of course, the very core of the Laboratory SOS & PePSy. Without efficient synthetic methods to obtain our molecules of interest, like non-natural aminoacids, peptides, oligomers, natural and bioactive compounds, further applications would not be possible. Particular attention is paid to the development of green methods, thanks to the use of catalytic reactions, supported catalysis and flux chemistry. Global issues like climate change, water shortages and natural resource scarcity, challenge particularly chemistry to find high yielding methods with a lower environmental impact, to develop a suistainable world.