Stabilized Arylzinc Iodides in Negishi Acylative Cross-Coupling

I am really proud to share this work wrote  by Post-Doc Dr. Gianluca Casotti, as corresponding author, that was recently published on the new journal "Organics". In our laboratory Sos & PePSy, and in our department of chemistry in Pisa, through fruitful collaborations, we try to enhance the value of good ideas and good will. Gianluca had a good idea, and with my collegue Prof. Anna Iuliano we believed on it. The method developed allowed the synthesis of chalcones through a path involving an acylative Negishi coupling. The key point of this strategy is the preparation of the organozinc by direct insertion which is reflected in a superior functional-group tolerance and an improved intrinsic greenness. Different functional groups as well as heteroaryl rings are well-tolerated. 

𝐂𝐡𝐞𝐦𝐨𝐛𝐫𝐢𝐨𝐧𝐢𝐜𝐬 𝐌𝐞𝐞𝐭𝐢𝐧𝐠 𝐏𝐈𝐒𝐀 𝟐𝟎𝟐𝟐

I a thrilled and honoured to host here, at the University of Pisa (5-6-7 September) the last Chemobrionics meeting. A great chance to meet several Scientists from all over Europe, with a reach agenda of lectures!

Self-organizing precipitation processes, such as chemical gardens forming biomimetic micro- and nano-tubular forms, Self-assembly of amphiphilic molecules forming micelles, vesicles or membrane, have the potential to drastically enhance future materials design, as well as allowing us to develop new methodologies to explore, quantify and understand non-equilibrium chemical systems, and might even shed light on the conditions for the origin of life. Advances in chemobrionics require a combination of expertise in physics, chemistry, mathematical modelling, biology and engineering, as well as in nonlinear and materials sciences, giving rise to a new synergistic disipline.

If you are interested visit the website: https://www.chemobrionics.eu/pisa

Benvenuti Ludovica e Ferdinando

Diamo il benvenuto a Ferdinando Fierro e Ludovica Dei che hanno iniziato contemporaneamente il loro tirocinio di tesi magistrale! Ferdinando lavorerà su di un progetto in collaborazione con il Prof. Pescitelli sulla sintesi di mimetici peptidici e il loro studio conformazionale tramite metodi chiroottici, mentre Ludovica lavorerà su di un progetto in collaborazione con la Prof.ssa Di Bussolo e il Dr. Di Pietro, sulla sintesi di molecole anfifiliche e lo studio del loro self-assembly. A entrambi i migliori auguri per un buon inizio!

Aut viam inveniam aut faciam!

Really lucky to have a talented Post-Doc like Gianluca in the Lab! He is working on the Design & Synthesis of new photoswitches for biomedical applications in the Quantum LIP project,  a joint venture between the Molecolab of Prof. Benedetta Mennucci and our lab. SoS&PePsy. Not only Gianluca is able to move from computational to synthetic chemistry but he builded with 3D printer and Arduino a temperature-controlled photoreactor to be used directly on cuvettes and nmr tubes. Great Job!