Course Program
- Introduction, principles and history of Combinatorial Chemistry
- Methods and Techniques in Combi Chem
- Characterizations of combinatorial library
- Overview on the use of combi chem in medicinal chemistry
- Critics and perspective to combi chem
- Examples of combi chem in medicinal chemistry
- Automation and data processing
- Multicomponent reactions (Biginelli, Passerini, Ugi etc.)
- Tandem-domino reactions
- Bioconjugation methods
- Bioorthogonal reactions
- Non-covalent bioconjugation strategies
- Dynamic Combinatorial Chemistry, introduction, history and perspective
- Exchange reactions
- Developing of synthetic receptors using DCLs
- Ligands for Biomolecules
- Polymers formed by DCC
- Systems chemistry
- Erwin Schrödinger’s most famous question, what is life?
- Prebiotic Chemistry. Molecular network interactions and equilibrium
- Asymmetric synthesis in enantioselective autocatalytic reactions
- Speculations on chemical evolution. DNA and RNA in chemical evolvable systems
- The role of amphiphilic interactions on the formation of supramolecular structures